Plotegher, N;
Filadi, R;
Pizzo, P;
Duchen, MR;
(2021)
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown.
Trends in Neurosciences
, 44
(5)
pp. 342-351.
10.1016/j.tins.2021.01.001.
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Abstract
Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate. In fact, mitochondria sustain cell bioenergetics, tune intracellular Ca2+ dynamics, and regulate glutamate availability by using it as metabolic substrate. Here, we suggest the need to explore glutamate toxicity in the context of specific disease models in which it may occur, re-evaluating the impact of mitochondrial dysfunction on glutamate excitotoxicity. Our aim is to signpost new approaches, perhaps combining glutamate and pathways to rescue mitochondrial function, as therapeutic targets in neurological disorders.
| Type: | Article |
|---|---|
| Title: | Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tins.2021.01.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.tins.2021.01.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | bioenergetics, calcium, cell death, glutamate, mitochondria, neurodegeneration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10122786 |
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