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Case-finding strategies in non-alcoholic fatty liver disease

Boursier, J; Tsochatzis, EA; (2021) Case-finding strategies in non-alcoholic fatty liver disease. JHEP Reports , 3 (2) , Article 100219. 10.1016/j.jhepr.2020.100219. Green open access

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Abstract

Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, leading to poor clinical outcomes. Accumulating evidence suggests that using non-invasive tests for liver fibrosis in patients with metabolic risk factors improves the detection of patients in need of specialised management and is cost-effective. Because of the vast number of patients requiring evaluation, the active participation of general practitioners and physicians who manage patients with metabolic disorders, such as diabetologists, is crucial; this calls for the increased awareness of NAFLD beyond liver clinics. Non-invasive case-finding strategies will need to be further validated and generalised for upcoming drug therapies to have the required impact on the worldwide burden of NAFLD.

Type: Article
Title: Case-finding strategies in non-alcoholic fatty liver disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhepr.2020.100219
Publisher version: https://doi.org/10.1016/j.jhepr.2020.100219
Language: English
Additional information: © 2020 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Liver fibrosis; Elastography; Screening; Case-finding; Patient pathway; Primary care; Type 2 diabetes mellitus; Costeffectiveness; Awareness; FIB-4; Cirrhosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10122723
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