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Hippocampal place cells encode global location but not connectivity in a complex space

Duvelle, É; Grieves, RM; Liu, A; Jedidi-Ayoub, S; Holeniewska, J; Harris, A; Nyberg, N; ... Spiers, HJ; + view all (2021) Hippocampal place cells encode global location but not connectivity in a complex space. Current Biology 10.1016/j.cub.2021.01.005. (In press). Green open access

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Abstract

Flexible navigation relies on a cognitive map of space, thought to be implemented by hippocampal place cells: neurons that exhibit location-specific firing. In connected environments, optimal navigation requires keeping track of one’s location and of the available connections between subspaces. We examined whether the dorsal CA1 place cells of rats encode environmental connectivity in four geometrically identical boxes arranged in a square. Rats moved between boxes by pushing saloon-type doors that could be locked in one or both directions. Although rats demonstrated knowledge of environmental connectivity, their place cells did not respond to connectivity changes, nor did they represent doorways differently from other locations. Place cells coded location in a global reference frame, with a different map for each box and minimal repetitive fields despite the repetitive geometry. These results suggest that CA1 place cells provide a spatial map that does not explicitly include connectivity.

Type: Article
Title: Hippocampal place cells encode global location but not connectivity in a complex space
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2021.01.005
Publisher version: https://doi.org/10.1016/j.cub.2021.01.005
Language: English
Additional information: Copyright © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: detour, four-room maze, hippocampus, navigation, place cells, place field repetition, rat, spatial connectivity, topology, transitions
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10122401
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