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Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal

Dangond, F; Donnelly, A; Hohlfeld, R; Lubetzki, C; Kohlhaas, S; Leocani, L; Ciccarelli, O; ... Salvetti, M; + view all (2021) Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal. Nature Reviews Neurology , 17 pp. 185-192. 10.1038/s41582-020-00446-9. Green open access

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Abstract

Therapies for infiltrative inflammation in multiple sclerosis (MS) have advanced greatly, but neurodegeneration and compartmentalized inflammation remain virtually untargeted as in other diseases of the nervous system. Consequently, many therapies are available for the relapsing–remitting form of MS, but the progressive forms remain essentially untreated. The objective of the International Progressive MS Alliance is to expedite the development of effective therapies for progressive MS through new initiatives that foster innovative thinking and concrete advancements. Based on these principles, the Alliance is developing a new funding programme that will focus on experimental medicine trials. Here, we discuss the reasons behind the focus on experimental medicine trials, the strengths and weaknesses of these approaches and of the programme, and why we hope to advance therapies while improving the understanding of progression in MS. We are soliciting public and academic feedback, which will help shape the programme and future strategies of the Alliance.

Type: Article
Title: Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41582-020-00446-9
Publisher version: https://doi.org/10.1038/s41582-020-00446-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Multiple sclerosis, Therapeutics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10122238
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