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Metal Storage Disorders: Inherited Disorders of Copper and Manganese Metabolism and Movement Disorders.

Clayton, P; Tuschl, K; (2020) Metal Storage Disorders: Inherited Disorders of Copper and Manganese Metabolism and Movement Disorders. In: Ebrahimi-Fakhari, D and Pearl, P, (eds.) Movement Disorders and Inherited Metabolic Disorders: Recognition, Understanding, Improving Outcomes. (pp. 230-243). Cambridge University Press: Cambridge, UK. Green open access

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Abstract

Copper is one of the six transition metals that have important biochemical roles in humans, particularly in catalysis and electron transport [1, 2]. Because it can exist in two redox states (Cu2+/Cu+), it can participate in redox reactions involving transfer of an electron, but if it builds up it can also generate potentially toxic reactive oxygen species by Fenton chemistry. Examples of copper in redox enzymes include: complex IV of the mitochondrial respiratory chain, copper–zinc superoxide dismutase, ceruloplasmin (ferroxidase), lysyl oxidase, dopamine beta-hydroxylase, and tyrosinase.

Type: Book chapter
Title: Metal Storage Disorders: Inherited Disorders of Copper and Manganese Metabolism and Movement Disorders.
ISBN-13: 9781108556767
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/9781108556767
Publisher version: https://doi.org/10.1017/9781108556767
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10122113
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