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Morphological Change Forecasting for Prostate Glands using Feature-based Registration and Kernel Density Extrapolation

Yang, Q; Vercauteren, T; Fu, Y; Giganti, F; Ghavami, N; Stavrinides, V; Moore, CM; ... Hu, Y; + view all (2021) Morphological Change Forecasting for Prostate Glands using Feature-based Registration and Kernel Density Extrapolation. In: Proceedings of the International Symposium on Biomedical Imaging (IEEE ISBI 2021). IEEE: Virtual conference. (In press). Green open access

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Abstract

Organ morphology is a key indicator for prostate disease diagnosis and prognosis. For instance, In longitudinal study of prostate cancer patients under active surveillance, the volume, boundary smoothness and their changes are closely monitored on time-series MR image data. In this paper, we describe a new framework for forecasting prostate morphological changes, as the ability to detect such changes earlier than what is currently possible may enable timely treatment or avoiding unnecessary confirmatory biopsies. In this work, an efficient feature-based MR image registration is first developed to align delineated prostate gland capsules to quantify the morphological changes using the inferred dense displacement fields (DDFs). We then propose to use kernel density estimation (KDE) of the probability density of the DDFrepresented future morphology changes, between current and future time points, before the future data become available. The KDE utilises a novel distance function that takes into account morphology, stage-of-progression and duration-ofchange, which are considered factors in such subject-specific forecasting. We validate the proposed approach on image masks unseen to registration network training, without using any data acquired at the future target time points. The experiment results are presented on a longitudinal data set with 331 images from 73 patients, yielding an average Dice score of 0.865 on a holdout set, between the ground-truth and the image masks warped by the KDE-predicted-DDFs.

Type: Proceedings paper
Title: Morphological Change Forecasting for Prostate Glands using Feature-based Registration and Kernel Density Extrapolation
Event: International Symposium on Biomedical Imaging (IEEE ISBI 2021)
Open access status: An open access version is available from UCL Discovery
Publisher version: https://biomedicalimaging.org/2021/
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Feature-based registration, kernel density estimation, longitudinal data, active surveillance, deep learning
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10121946
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