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Natural products in drug discovery: advances and opportunities

Atanasov, AG; Zotchev, SB; Dirsch, VM; Orhan, IE; Banach, M; Rollinger, JM; Barreca, D; ... Supuran, CT; + view all (2021) Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery 10.1038/s41573-020-00114-z. (In press). Green open access

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Abstract

Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.

Type: Article
Title: Natural products in drug discovery: advances and opportunities
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41573-020-00114-z
Publisher version: https://doi.org/10.1038/s41573-020-00114-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chemical biology, Transferases
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10121490
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