UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Long-Term Outcomes of Everolimus Therapy in De Novo Liver Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Bzeizi, KI; Smith, R; Albenmousa, A; Dama, M; Aba-Alkhail, F; Jalan, R; Broering, D; (2021) Long-Term Outcomes of Everolimus Therapy in De Novo Liver Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Transplantation Proceedings , 53 (1) pp. 148-158. 10.1016/j.transproceed.2020.09.021.

[img] Text (Article)
Jalan_EVEROLIMUS Manuscript.pdf - Accepted version
Access restricted to UCL open access staff until 2 January 2022.

Download (360kB)
[img] Text (Highlights)
Jalan_Highlights (1).pdf
Access restricted to UCL open access staff until 2 January 2022.

Download (47kB)
[img] Image (Figure 1)
Jalan_Figure 1.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (98kB)
[img] Image (Figure 2)
Jalan_Figure 2.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (264kB)
[img] Image (Figure 3)
Jalan_Figure 3.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (198kB)
[img] Image (Figure 4)
Jalan_Figure 4ab.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (766kB)
[img] Image (Figure 5)
Jalan_Figure 5ab.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (565kB)
[img] Image (Figure 6)
Jalan_Figure 6ab.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (529kB)
[img] Image (Figure 7)
Jalan_Figure 7ab.jpg
Access restricted to UCL open access staff until 2 January 2022.

Download (609kB)
[img] Text (Table 1)
Jalan_Table - 1.pdf
Access restricted to UCL open access staff until 2 January 2022.

Download (92kB)
[img] Text (Table 2)
Jalan_Table - 2.pdf
Access restricted to UCL open access staff until 2 January 2022.

Download (28kB)
[img] Text (Table 3)
Jalan_Table - 3.pdf
Access restricted to UCL open access staff until 2 January 2022.

Download (33kB)

Abstract

BACKGROUND: Risk of nephrotoxicity in liver transplant patients on calcineurin inhibitors (CnIs) is a concern. Several controlled trials reported benefit of everolimus (EVR) in minimizing this risk when combined with a reduced CnI dose. BACKGROUND: To systematically review the efficacy and safety of EVR, alone or with reduced CnI dose, as compared to CnI alone post-liver transplantation. METHODS: We searched MEDLINE, Scopus, and the Cochrane Library for randomized controlled trials comparing EVR- and CnI-based regimens post-liver transplantation. Assessment of studies and data extraction were undertaken independently. RESULTS: Eight studies were selected, describing 769 patients. Cockcroft-Gault GFR was higher at one (P = .05), 3, and 5 years (P = .030) in patients on EVR compared to those receiving CnI therapy. The composite endpoint of efficacy failure was similar between the 2 arms after 1, 3, and 5 years of study. More patients discontinued EVR due to adverse effects in 1 year; however, no difference was noted after 3 or 5 years. A higher rates of proteinuria, peripheral edema, and incisional hernia occurred in patients on EVR. CONCLUSIONS: The analysis confirms noninferiority of EVR and reduced CnI combination. Combination regimen resulted in better renal function compared to standard CnI therapy.

Type: Article
Title: Long-Term Outcomes of Everolimus Therapy in De Novo Liver Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Location: United States
DOI: 10.1016/j.transproceed.2020.09.021
Publisher version: https://doi.org/10.1016/j.transproceed.2020.09.021
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10121168
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item