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Nanozyme-amplified lateral flow immunoassay for molecular signature detection of cardiovascular diseases

Broto, M; Chen, B; Thomas, MR; Wood, CS; Lota, AS; Prasad, S; Stevens, MM; (2019) Nanozyme-amplified lateral flow immunoassay for molecular signature detection of cardiovascular diseases. In: Proceedings of the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. (pp. pp. 1202-1203). MicroTAS: Basel, Switzerland. Green open access

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Abstract

Point-of-care (PoC) devices offer the opportunity to decentralize the analysis of biomarkers in biological fluids thus providing patients with more personalized medicine. The golden standard of PoC platforms are lateral flow assays since they are low cost, quick to perform and user-friendly [1]. Here we show the use of a nanozyme-mediated signal readout on a multiplexed PoC lateral flow immunoassay for the diagnosis of cardiovascular diseases. Our aim has been to expand the application of this ultrasensitive detection method towards the development of a multiplexed PoC assay for cardiovascular-related biomarkers to support triage of myocardial injury.

Type: Proceedings paper
Title: Nanozyme-amplified lateral flow immunoassay for molecular signature detection of cardiovascular diseases
Event: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
ISBN-13: 9781733419000
Open access status: An open access version is available from UCL Discovery
Publisher version: https://www.microtas2019.org/
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multiplexed, Paper-based, Platinum particles, Cardiovascular diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10121028
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