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Development and validation of a self-report measure of practical barriers to medication adherence - the Medication Practical barriers to Adherence Questionnaire (MPRAQ)

Chan, AHY; Vervloet, M; Lycett, H; Brabers, A; van Dijk, L; Horne, R; (2021) Development and validation of a self-report measure of practical barriers to medication adherence - the Medication Practical barriers to Adherence Questionnaire (MPRAQ). British Journal of Clinical Pharmacology 10.1111/bcp.14744. (In press).

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Abstract

AIM: This study reports the development and validation of a new self-report measure (MPRAQ) that assesses practical barriers to medication adherence. METHODS: MPRAQ comprises fifteen statements describing practical barriers. Responses are scored on a 5-point Likert scale; higher scores indicate more practical barriers. Initial face validity was evaluated by cognitive testing with patients from a diabetes support group. Following refinement, internal reliability and construct validity were assessed in two samples: patients recruited via Amazon mTurk and the Nivel Dutch Healthcare Consumer Panel (COPA). Respondents completed the Beliefs about Medicines Questionnaire (BMQ - general and specific), and Medication Adherence Report Scale (MARS-5). The mTurk sample also completed the Perceived Sensitivity to Medicines questionnaire (PSM), and repeated MPRAQ two weeks later to assess test-retest reliability. RESULTS: Face validity was evaluated in 15 patients (46% female; mean (SD) age 64(12) years). A total of 184 mTurk participants completed the questionnaire (in English) and 334 in COPA (in Dutch). Internal reliability was acceptable (mTurk α=0.89; COPA α=0.94). Construct validity was confirmed, with significant correlation between MPRAQ and BMQ-Specific Concerns (mTurk r=0.546, p<0.0001; COPA r=0.370, p<0.0001); BMQ-General Harm (mTurk r=0.504, p<0.0001; COPA r=0.219, p<0.0001); BMQ-General Overuse (mTurk, r=0.324, p<0.0001; COPA r=0.109, p=0.047), and PSM (mTurk only, r=0.463, p<0.0001), and a negative correlation with MARS-5 (mTurk r=-0.450, p<0.0001; COPA r=-0.260, p<0.0001). MPRAQ did not correlate with BMQ-Specific Necessity or BMQ-General Benefit. Correlation between MPRAQ baseline and 2-week follow-up scores confirmed test-retest reliability (r=0.745, p<0.0001; n=52). CONCLUSION: MPRAQ is a reliable and valid self-report measure of practical adherence barriers.

Type: Article
Title: Development and validation of a self-report measure of practical barriers to medication adherence - the Medication Practical barriers to Adherence Questionnaire (MPRAQ)
Location: England
DOI: 10.1111/bcp.14744
Publisher version: http://dx.doi.org/10.1111/bcp.14744
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Adherence, MPRAQ, barriers, measure, medication, practicalities, questionnaire, validation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: https://discovery.ucl.ac.uk/id/eprint/10120863
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