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Fluid mechanical modeling of the upper urinary tract

Zheng, S; Carugo, D; Mosayyebi, A; Turney, B; Burkhard, F; Lange, D; Obrist, D; ... Clavica, F; + view all (2021) Fluid mechanical modeling of the upper urinary tract. WIREs Mechanisms of Disease , Article e01523. 10.1002/wsbm.1523. (In press). Green open access

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Abstract

The upper urinary tract (UUT) consists of kidneys and ureters, and is an integral part of the human urogenital system. Yet malfunctioning and complications of the UUT can happen at all stages of life, attributed to reasons such as congenital anomalies, urinary tract infections, urolithiasis and urothelial cancers, all of which require urological interventions and significantly compromise patients' quality of life. Therefore, many models have been developed to address the relevant scientific and clinical challenges of the UUT. Of all approaches, fluid mechanical modeling serves a pivotal role and various methods have been employed to develop physiologically meaningful models. In this article, we provide an overview on the historical evolution of fluid mechanical models of UUT that utilize theoretical, computational, and experimental approaches. Descriptions of the physiological functionality of each component are also given and the mechanical characterizations associated with the UUT are provided. As such, it is our aim to offer a brief summary of the current knowledge of the subject, and provide a comprehensive introduction for engineers, scientists, and clinicians who are interested in the field of fluid mechanical modeling of UUT.

Type: Article
Title: Fluid mechanical modeling of the upper urinary tract
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/wsbm.1523
Publisher version: https://doi.org/10.1002/wsbm.1523
Language: English
Additional information: Copyright © 2021 The Authors. WIREs Mechanisms of Disease published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: fluid mechanics, modeling, stent, urinary obstruction, urinary tract
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10120741
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