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Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects

Ray, JC; Kapoor, M; Stark, RJ; Wang, S-J; Bendtsen, L; Matharu, M; Hutton, EJ; (2021) Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects. Journal of Neurology, Neurosurgery & Psychiatry 10.1136/jnnp-2020-324674. (In press). Green open access

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Abstract

Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.

Type: Article
Title: Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2020-324674
Publisher version: https://doi.org/10.1136/jnnp-2020-324674
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10120530
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