Saso, S;
Tziraki, M;
Clancy, NT;
Song, L;
Bracewell-Milnes, T;
Jones, BP;
Al-Memar, M;
... Ghaem-Maghami, S; + view all
(2018)
Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model.
Future Science OA
, 4
(7)
, Article FSO324. 10.4155/fsoa-2018-0017.
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Abstract
Aim: Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx. Results/methodology: eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status. Conclusion: These preliminary results establish the potential of Laser Speckle Contrast Analysis as noncontact and real-time tool for observation of spatially-resolved blood flow from which other parameters can be derived.
| Type: | Article |
|---|---|
| Title: | Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4155/fsoa-2018-0017 |
| Publisher version: | https://doi.org/10.4155/fsoa-2018-0017 |
| Language: | English |
| Additional information: | This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| Keywords: | graft anastomosis, oxygen saturation, surgical imaging, tissue perfusion, uterine transplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10120497 |
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