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Glaucoma drainage devices: design, flow resistance and biocompatibility implications for intraocular pressure control

Henein, Christin; (2021) Glaucoma drainage devices: design, flow resistance and biocompatibility implications for intraocular pressure control. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

The overarching aim of this thesis is to develop a novel glaucoma drainage device that meets the ‘10-10-10’ goal for glaucoma treatment: specifically, a surgical intervention that can reduce the intraocular pressure to 10mmHg, can be implanted in 10 minutes and lasts for 10 years. The thesis encompasses elements from the research and design phase of device development to the preclinical and clinical testing of the device. The doctoral proposal is divided into four chapters. The first describes the role of minimally invasive surgery in the management of glaucoma; the second elucidates the physiochemical factors that impact the outflow facility of microtubes used in minimally invasive glaucoma surgery; the third presents a novel way to titrate aqueous outflow from a novel glaucoma microstent; finally, the fourth determines the bioburden, extractables and leachables of a novel glaucoma device, along with its implications for in vivo biocompatibility.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Glaucoma drainage devices: design, flow resistance and biocompatibility implications for intraocular pressure control
Event: University College London
Language: English
Additional information: Copyright © The Author 2021. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10120334
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