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Durotaxis: The Hard Path from In Vitro to In Vivo

Shellard, A; Mayor, R; (2021) Durotaxis: The Hard Path from In Vitro to In Vivo. Developmental Cell , 56 (2) pp. 227-239. 10.1016/j.devcel.2020.11.019. Green open access

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Abstract

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness, has been proposed as a mechanism driving directed migration. Despite the lack of evidence for its existence in vivo, durotaxis has become an active field of research, focusing on the mechanism by which cells respond to mechanical stimuli from the environment. In this review, we describe the technical and conceptual advances in the study of durotaxis in vitro, discuss to what extent the evidence suggests durotaxis may occur in vivo, and emphasize the urgent need for in vivo demonstration of durotaxis.

Type: Article
Title: Durotaxis: The Hard Path from In Vitro to In Vivo
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2020.11.019
Publisher version: https://doi.org/10.1016/j.devcel.2020.11.019
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cell migration, chemotaxis, durotaxis, mechanics, stiffness
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10120242
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