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Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease

Estevez-Fraga, C; Scahill, RI; Durr, A; Leavitt, BR; Roos, RAC; Langbehn, DR; Rees, G; ... Tabrizi, SJ; + view all (2021) Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease. Movement Disorders 10.1002/mds.28489. (In press).

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Abstract

Background: The composite Unified Huntington's Disease Rating Scale (cUHDRS) is a multidimensional measure of progression in Huntington's disease (HD) being used as a primary outcome in clinical trials investigating potentially disease‐modifying huntingtin‐lowering therapies. Objective: Evaluating volumetric and structural connectivity correlates of the cUHDRS. Methods: One hundred and nineteen premanifest and 119 early‐HD participants were included. Gray and white matter (WM) volumes were correlated with cUHDRS cross‐sectionally and longitudinally using voxel‐based morphometry. Correlations between baseline fractional anisotropy (FA); mean, radial, and axial diffusivity; and baseline cUHDRS were examined using tract‐based spatial statistics. Results: Worse performance in the cUHDRS over time correlated with longitudinal volume decreases in the occipito‐parietal cortex and centrum semiovale, whereas lower baseline scores correlated with decreased volume in the basal ganglia and surrounding WM. Lower cUHDRS scores were also associated with reduced FA and increased diffusivity at baseline. Conclusion: The cUHDRS correlates with imaging biomarkers and tracks atrophy progression in HD supporting its biological relevance.

Type: Article
Title: Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease
Location: United States
DOI: 10.1002/mds.28489
Publisher version: https://doi.org/10.1002/mds.28489
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Huntington’s disease, cUHDRS, diffusion tensor imaging, voxel-based morphometry, clinical trials, longitudinal
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10120237
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