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Combination of Structure-Performance and Shape-Performance Relationships for Better Biphasic Release in Electrospun Janus Fibers

Zheng, X; Kang, S; Wang, K; Yang, Y; Yu, D-G; Wan, F; Williams, GR; (2021) Combination of Structure-Performance and Shape-Performance Relationships for Better Biphasic Release in Electrospun Janus Fibers. International Journal of Pharmaceutics , 596 , Article 120203. 10.1016/j.ijpharm.2021.120203. (In press).

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Abstract

In nature, the combination of composition, structure, and shape determines the matter's functional performance to a large extent. Inspired by which, two electrospun Janus nanofiber formulations were created using side-by-side electrospinning in this work. Tamoxifen citrate (TAM) was used as a model drug and ethyl cellulose (EC) and polyvinylpyrrolidone K60 (PVP) as the polymer carrier matrices. The fibers have linear cylindrical morphologies and distinct Janus structures by scanning electron microscopy. One side of the fibers took a round shape, while the other was crescent-shaped. The drug was present in both polymer matrices in the form of amorphous solid dispersions, owing to strong intermolecular interactions between drug and polymer. In vitro dissolution tests demonstrated that both sets of fibers could provide biphasic drug release due to the difference in solubility of PVP and EC. The different shape of TAM-EC and TAM-PVP side of the Janus structure resulted in a considerable variation in the drug release profiles. The Janus structure with crescent TAM-PVP side and round TAM-EC side gave a more rapid burst release in the first phase of release, and slower sustained release in the second phase. This work thus reports a new strategy for systematically developing advanced functional nanomaterials based on both shape- and structure-performance relationships.

Type: Article
Title: Combination of Structure-Performance and Shape-Performance Relationships for Better Biphasic Release in Electrospun Janus Fibers
Location: Netherlands
DOI: 10.1016/j.ijpharm.2021.120203
Publisher version: https://doi.org/10.1016/j.ijpharm.2021.120203
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Side-by-side electrospinning; Janus nanostructure; shape-performance relationship; side allocation; biphasic release
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10120085
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