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The complex three-dimensional organization of epithelial tissues

Gómez-Gálvez, P; Vicente-Munuera, P; Anbari, S; Buceta, J; Escudero, LM; (2021) The complex three-dimensional organization of epithelial tissues. Development , 148 (1) , Article dev195669. 10.1242/dev.195669. Green open access

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Abstract

Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex problem, researchers have taken advantage of reductionist approaches to reveal fundamental morphogenetic mechanisms and quantitative laws. For epithelia, their two-dimensional representation as polygonal tessellations has proved successful for understanding tissue organization. Yet, epithelial tissues bend and fold to shape organs in three dimensions. In this context, epithelial cells are too often simplified as prismatic blocks with a limited plasticity. However, there is increasing evidence that a realistic approach, even from a reductionist perspective, must include apico-basal intercalations (i.e. scutoidal cell shapes) for explaining epithelial organization convincingly. Here, we present an historical perspective about the tissue organization problem. Specifically, we analyze past and recent breakthroughs, and discuss how and why simplified, but realistic, in silico models require scutoidal features to address key morphogenetic events.

Type: Article
Title: The complex three-dimensional organization of epithelial tissues
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.195669
Publisher version: http://dx.doi.org/10.1242/dev.195669
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Apico-basal cell intercalation, Biophysical modeling, Cell shape, Mathematical modeling, Scutoid, Three-dimensional cell packing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10120040
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