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Adaptive optics: principles and applications in ophthalmology

Akyol, E; Hagag, AM; Sivaprasad, S; Lotery, AJ; (2020) Adaptive optics: principles and applications in ophthalmology. Eya , 35 pp. 244-264. 10.1038/s41433-020-01286-z. Green open access

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Abstract

This is a comprehensive review of the principles and applications of adaptive optics (AO) in ophthalmology. It has been combined with flood illumination ophthalmoscopy, scanning laser ophthalmoscopy, as well as optical coherence tomography to image photoreceptors, retinal pigment epithelium (RPE), retinal ganglion cells, lamina cribrosa and the retinal vasculature. In this review, we highlight the clinical studies that have utilised AO to understand disease mechanisms. However, there are some limitations to using AO in a clinical setting including the cost of running an AO imaging service, the time needed to scan patients, the lack of normative databases and the very small size of area imaged. However, it is undoubtedly an exceptional research tool that enables visualisation of the retina at a cellular level.

Type: Article
Title: Adaptive optics: principles and applications in ophthalmology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41433-020-01286-z
Publisher version: https://doi.org/10.1038/s41433-020-01286-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10119576
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