Kelada, M;
Hill, D;
Yap, TE;
Manzar, H;
Cordeiro, MF;
(2021)
Innovations and revolutions in reducing retinal ganglion cell loss in glaucoma.
Expert Review of Ophthalmology
, 16
(1)
pp. 33-46.
10.1080/17469899.2021.1835470.
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Abstract
Introduction: Glaucoma remains the leading cause of irreversible blindness. Although the loss of retinal ganglion cells (RGCs) is an established hallmark of glaucoma, reduction of intraocular pressure (IOP) is a widely used evidence-based management approach, even in normotensive patients. However, despite optimal pressure control, some patients progress to lose vision. / Areas covered: This review provides a summary of the latest methods aimed at reducing RGC loss with the objective of preserving vision, categorized by the mechanism of action. We discuss both the newest ways in which IOP can be reduced, alongside ‘pressure-independent’ pharmacological therapies and developments in bioengineering. The conducted PubMed search included the terms: ‘glaucoma pathophysiology,’ ‘IOP-lowering agents,’ ‘retinal ganglion cell apoptosis,’ ‘neuroprotection,’ ‘stem cells,’ ‘imaging.’ / Expert opinion: With many agents failing to successfully translate into clinical use, further understanding of the underlying disease process is required, along with novel biomarkers that will enable timely and reliable quantification of treatment effect.
Type: | Article |
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Title: | Innovations and revolutions in reducing retinal ganglion cell loss in glaucoma |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1080/17469899.2021.1835470 |
Publisher version: | https://doi.org/10.1080/17469899.2021.1835470 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Apoptosis, excitotoxicity, glaucoma, neuroprotection, neurotrophic factors, stem cells |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10119575 |
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