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Singlet oxygen stimulates mitochondrial bioenergetics in brain cells.

Sokolovski, SG; Rafailov, EU; Abramov, AY; Angelova, PR; (2021) Singlet oxygen stimulates mitochondrial bioenergetics in brain cells. Free Radical Biology and Medicine , 163 pp. 306-313. 10.1016/j.freeradbiomed.2020.12.022. Green open access

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Abstract

Oxygen, in form of reactive oxygen species (ROS), has been shown to participate in oxidative stress, one of the major triggers for pathology, but also is a main contributor to physiological processes. Recently, it was found that 1267 nm irradiation can produce singlet oxygen without photosensitizers. We used this phenomenon to study the effect of laser-generated singlet oxygen on one of the major oxygen-dependent processes, mitochondrial energy metabolism. We have found that laser-induced generation of 1O2 in neurons and astrocytes led to the increase of mitochondrial membrane potential, activation of NADH- and FADH-dependent respiration, and importantly, increased the rate of maximal respiration in isolated mitochondria. The activation of mitochondrial respiration stimulated production of ATP in these cells. Thus, we found that the singlet oxygen generated by 1267 nm laser pulse works as an activator of mitochondrial respiration and ATP production in the brain.

Type: Article
Title: Singlet oxygen stimulates mitochondrial bioenergetics in brain cells.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.freeradbiomed.2020.12.022
Publisher version: https://doi.org/10.1016/j.freeradbiomed.2020.12.02...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 1267 nm, Brain, Energy metabolism, Mitochondrial respiration, Singlet oxygen
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10119374
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