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Inbuilt Tendency of the eIF2 Regulatory System to Counteract Uncertainties

Khan, MF; Spurgeon, SK; Yan, XG; Nofal, MM; Al-Hmouz, R; (2021) Inbuilt Tendency of the eIF2 Regulatory System to Counteract Uncertainties. IEEE Transactions on Nanobioscience , 20 (1) pp. 35-41. 10.1109/TNB.2020.3022415. Green open access

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Abstract

Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the regulation of eIF2 is robust against intrinsic uncertainties and is able to efficiently counteract them. The robustness properties of the eIF2 pathway against intrinsic disturbances is also well known. However the reasons for this ability to counteract stresses is less well understood. In this article, the robustness conferring properties of the eIF2 dependent regulatory system is explored with the help of a mathematical model. The novelty of the work presented in this article lies in articulating the possible reason behind the inbuilt robustness of the highly engineered eIF2 system against intrinsic perturbations. Our investigations reveal that the robust nature of the eIF2 pathway may originate from the existence of an attractive natural sliding surface within the system satisfying reaching and sliding conditions that are well established in the domain of control engineering.

Type: Article
Title: Inbuilt Tendency of the eIF2 Regulatory System to Counteract Uncertainties
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TNB.2020.3022415
Publisher version: https://doi.org/10.1109/TNB.2020.3022415
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Protein synthesis, mathematical modelling, linearisation, key non-linearities, stability, sliding surface
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10119322
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