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A Geroscience approach for Parkinson's Disease: conceptual framework and design of PROPAG-AGEING project

Pirazzini, C; Azevedo, T; Baldelli, L; Bartoletti-Stella, A; Calandra-Buonaura, G; Molin, AD; Dimitri, GM; ... PROPAG-AGEING Consortium, ; + view all (2020) A Geroscience approach for Parkinson's Disease: conceptual framework and design of PROPAG-AGEING project. Mechanisms of Ageing and Development 10.1016/j.mad.2020.111426. (In press). Green open access

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Abstract

Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project "PROPAG-AGEING", whose aim is to characterize the contribution of the ageing process to PD development. We summarize current evidences that support the existence of a continuum between ageing and PD and justify the use of a Geroscience approach to study PD. We focus in particular on the role of inflammaging, the chronic, low-grade inflammation characteristic of elderly physiology, which can propagate and transmit both locally and systemically. We then describe PROPAG-AGEING design, which is based on the multi-omic characterization of peripheral samples from clinically characterized drug-naïve and advanced PD, PD discordant twins, healthy controls and "super-controls", i.e. centenarians, who never showed clinical signs of motor disability, and their offspring. Omic results are then validated in a large number of samples, including in vitro models of dopaminergic neurons and healthy siblings of PD patients, who are at higher risk of developing PD, with the final aim of identifying the molecular perturbations that can deviate the trajectories of healthy ageing towards PD development.

Type: Article
Title: A Geroscience approach for Parkinson's Disease: conceptual framework and design of PROPAG-AGEING project
Location: Ireland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mad.2020.111426
Publisher version: https://doi.org/10.1016/j.mad.2020.111426
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Parkinson's disease, inflammaging, neurodegeneration, omics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10119016
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