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The sensory representation of causally controlled objects

Clancy, KB; Mrsic-Flogel, TD; (2020) The sensory representation of causally controlled objects. Neuron 10.1016/j.neuron.2020.12.001. (In press). Green open access

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Abstract

Intentional control over external objects is informed by our sensory experience of them. To study how causal relationships are learned and effected, we devised a brain machine interface (BMI) task using wide-field calcium signals. Mice learned to entrain activity patterns in arbitrary pairs of cortical regions to guide a visual cursor to a target location for reward. Brain areas that were normally correlated could be rapidly reconfigured to exert control over the cursor in a sensory-feedback-dependent manner. Higher visual cortex was more engaged when expert but not naive animals controlled the cursor. Individual neurons in higher visual cortex responded more strongly to the cursor when mice controlled it than when they passively viewed it, with the greatest response boosting as the cursor approached the target location. Thus, representations of causally controlled objects are sensitive to intention and proximity to the subject’s goal, potentially strengthening sensory feedback to allow more fluent control.

Type: Article
Title: The sensory representation of causally controlled objects
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2020.12.001
Publisher version: https://doi.org/10.1016/j.neuron.2020.12.001
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: brain computer interface, brain machine interface, calcium imaging, causal control, decoder, neuroprosthetics, parietal cortex, sensorimotor learning, visual cortex, widefield imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10118919
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