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Targeting the Bacterial protective armour; challenges and novel strategies in the treatment of microbial biofilm

Kamaruzzaman, NF; Tan, LP; Yazid, KAM; Saeed, SI; Hamdan, RH; Choong, SS; Wong, WK; ... Gibson, AJ; + view all (2018) Targeting the Bacterial protective armour; challenges and novel strategies in the treatment of microbial biofilm. Materials , 11 (9) , Article 1705. 10.3390/ma11091705. Green open access

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Abstract

Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.

Type: Article
Title: Targeting the Bacterial protective armour; challenges and novel strategies in the treatment of microbial biofilm
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ma11091705
Publisher version: https://doi.org/10.3390/ma11091705
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/
Keywords: biofilms; anti-biofilms; nosocomial pathogens; Staphylococcus aureus; Pseudomonas aeruginosa; Klebsiella pneumoniae
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10118720
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