Barnes, NG;
Nyandoro, K;
Jin, H;
Macmillan, D;
(2021)
Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation.
Chemical Communications
10.1039/D0CC07404G.
(In press).
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Abstract
Head-to-sidechain macrocylic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid sidechain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening of the corresponding Na-Fmoc protected anhydride precursors.
Type: | Article |
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Title: | Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1039/D0CC07404G |
Publisher version: | https://doi.org/10.1039/D0CC07404G |
Language: | English |
Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/ |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
URI: | https://discovery.ucl.ac.uk/id/eprint/10118687 |
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