UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis

M Leite, D; Matias, D; Battaglia, G; (2020) The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis. Cells , 9 (12) , Article 2685. 10.3390/cells9122685. Green open access

[thumbnail of cells-09-02685-v2.pdf]
Preview
Text
cells-09-02685-v2.pdf - Published Version

Download (1MB) | Preview

Abstract

Within the brain, endothelial cells lining the blood vessels meticulously coordinate the transport of nutrients, energy metabolites and other macromolecules essential in maintaining an appropriate activity of the brain. While small molecules are pumped across specialised molecular transporters, large macromolecular cargos are shuttled from one side to the other through membrane-bound carriers formed by endocytosis on one side, trafficked to the other side and released by exocytosis. Such a process is collectively known as transcytosis. The brain endothelium is recognised to possess an intricate vesicular endosomal network that mediates the transcellular transport of cargos from blood-to-brain and brain-to-blood. However, mounting evidence suggests that brain endothelial cells (BECs) employ a more direct route via tubular carriers for a fast and efficient transport from the blood to the brain. Here, we compile the mechanism of transcytosis in BECs, in which we highlight intracellular trafficking mediated by tubulation, and emphasise the possible role in transcytosis of the Bin/Amphiphysin/Rvs (BAR) proteins and glycocalyx (GC)-a layer of sugars covering BECs, in transcytosis. Both BAR proteins and the GC are intrinsically associated with cell membranes and involved in the modulation and shaping of these membranes. Hence, we aim to summarise the machinery involved in transcytosis in BECs and highlight an uncovered role of BAR proteins and the GC at the brain endothelium.

Type: Article
Title: The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells9122685
Publisher version: https://doi.org/10.3390/cells9122685
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: BAR proteins, blood–brain barrier, endothelium, glycocalyx, transcytosis, tubulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10118450
Downloads since deposit
28Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item