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Oscillatory correlates of auditory working memory examined with human electrocorticography

Kumar, S; Gander, PE; Berger, JI; Billig, AJ; Nourski, KV; Oya, H; Kawasaki, H; ... Griffiths, TD; + view all (2021) Oscillatory correlates of auditory working memory examined with human electrocorticography. Neuropsychologia , 150 , Article 107691. 10.1016/j.neuropsychologia.2020.107691. Green open access

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Abstract

This work examines how sounds are held in auditory working memory (AWM) in humans by examining oscillatory local field potentials (LFPs) in candidate brain regions. Previous fMRI studies by our group demonstrated blood oxygenation level-dependent (BOLD) response increases during maintenance in auditory cortex, inferior frontal cortex and the hippocampus using a paradigm with a delay period greater than 10s. The relationship between such BOLD changes and ensemble activity in different frequency bands is complex, and the long delay period raised the possibility that long-term memory mechanisms were engaged. Here we assessed LFPs in different frequency bands in six subjects with recordings from all candidate brain regions using a paradigm with a short delay period of 3 s. Sustained delay activity was demonstrated in all areas, with different patterns in the different areas. Enhancement in low frequency (delta) power and suppression across higher frequencies (beta/ gamma) were demonstrated in primary auditory cortex in medial Heschl’s gyrus (HG) whilst non-primary cortex showed patterns of enhancement and suppression that altered at different levels of the auditory hierarchy from lateral HG to superior- and middle-temporal gyrus. Inferior frontal cortex showed increasing suppression with increasing frequency. The hippocampus and parahippocampal gyrus showed low frequency increases and high frequency decreases in oscillatory activity. This work demonstrates sustained activity patterns during AWM maintenance, with prominent low-frequency increases in medial temporal lobe regions.

Type: Article
Title: Oscillatory correlates of auditory working memory examined with human electrocorticography
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2020.107691
Publisher version: https://doi.org/10.1016/j.neuropsychologia.2020.10...
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Electrocorticography, Auditory working memory, Neurophysiology, Oscillatory activity, Hippocampus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10118414
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