Kundu, K;
Afshar, A;
Katti, DR;
Edirisinghe, M;
Katti, KS;
(2021)
Composite nanoclay-hydroxyapatite-polymer fiber scaffolds for bone tissue engineering manufactured using pressurized gyration.
Composites Science and Technology
, 202
, Article 108598. 10.1016/j.compscitech.2020.108598.
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Abstract
A novel fabrication of polymer composite fibers using polycaprolactone (PCL), montmorillonite nanoclay (MMT-Clay), and nano-hydroxyapatite-clay (HAP MMT-Clay) is reported for bone tissue engineering applications. Using a pressurized gyration (PG) setup, polycaprolactone (PCL) fibers incorporated with in situ mineralized HAP MMT-Clay and MMT-Clay were investigated. Using the novel fabrication method, we were able to successfully manufacture HAP-nanoclay-PCL fibers. Further, 3D scaffolds made using the prepared fibers were able to enhance bone growth, cell viability, and proliferation. The results demonstrated that the polymer fiber scaffolds are biocompatible, and the cells were able to thrive and differentiate on the fiber scaffolds. A significant increase in cell viability, osteogenic differentiation, ECM formation, and collagen formation was observed with PCL HAP MMT-Clay fibers scaffolds compared to the behaviors in PCL fibers. Further, the intracellular ALP levels increased with PCL HAP MMT-Clay fiber scaffold, indicating enhanced osteogenic differentiation of MSCs. This work shows a promising outlook for the future of manufacturable composite nanoclay polymer fibers incorporated as scaffolds for bone tissue engineering applications.
| Type: | Article |
|---|---|
| Title: | Composite nanoclay-hydroxyapatite-polymer fiber scaffolds for bone tissue engineering manufactured using pressurized gyration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.compscitech.2020.108598 |
| Publisher version: | https://doi.org/10.1016/j.compscitech.2020.108598 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | biomaterial composites; fiber; biomaterials; bone; scaffolds; pressurized gyration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10118314 |
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