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Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes

Koster, R; Chadwick, MJ; Chen, Y; Berron, D; Banino, A; Duezel, E; Hassabis, D; (2018) Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes. Neuron , 99 (6) 1342-1354.e6. 10.1016/j.neuron.2018.08.009. Green open access

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Abstract

Recent evidence challenges the widely held view that the hippocampus is specialized for episodic memory, by demonstrating that it also underpins the integration of information across experiences. Contemporary computational theories propose that these two contrasting functions can be accomplished by big-loop recurrence, whereby the output of the system is recirculated back into the hippocampus. We use ultra-high-resolution fMRI to provide support for this hypothesis, by showing that retrieved information is presented as a new input on the superficial entorhinal cortex—driven by functional connectivity between the deep and superficial entorhinal layers. Further, the magnitude of this laminar connectivity correlated with inferential performance, demonstrating its importance for behavior. Our findings offer a novel perspective on information processing within the hippocampus and support a unifying framework in which the hippocampus captures higher-order structure across experiences, by creating a dynamic memory space from separate episodic codes for individual experiences.

Type: Article
Title: Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2018.08.009
Publisher version: https://doi.org/10.1016/j.neuron.2018.08.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10118276
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