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Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation

Tsutsumi, S; Chadney, O; Yiu, T-L; Bäumler, E; Faraggiana, L; Beau, M; Häusser, M; (2020) Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation. Cell Reports , 33 (12) , Article 108537. 10.1016/j.celrep.2020.108537. Green open access

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Abstract

Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning and correlates with enhanced temporal precision of motor initiation. These results suggest that both simple spikes and complex spikes govern sensory-driven motor initiation: simple spikes modulate its latency, and complex spikes refine its temporal precision, providing specific cellular substrates for cerebellar sensorimotor control.

Type: Article
Title: Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2020.108537
Publisher version: https://doi.org/10.1016/j.celrep.2020.108537
Language: English
Additional information: Copyright © 2020 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: purkinje cells, simple spikes, complex spikestwo-photon imaging, optogenetics, neuropixels, cerebellum, multisensory, timing, motor initiation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10118139
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