Beslow, LA;
Linds, AB;
Fox, CK;
Kossorotoff, M;
Zuñiga Zambrano, YC;
Hernández-Chávez, M;
Hassanein, SMA;
... International Pediatric Stroke Study Group; + view all
(2021)
Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2.
Annals of Neurology
, 89
(4)
pp. 657-665.
10.1002/ana.25991.
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Abstract
OBJECTIVE: Severe complications of SARS-CoV-2 include arterial ischemic stroke (AIS) in adults and pediatric multisystem inflammatory syndrome. Whether stroke is a frequent complication of pediatric SARS-CoV-2 is unknown. This study aimed to determine the proportion of pediatric SARS-CoV-2 cases with ischemic stroke and the proportion of pediatric strokes with SARS-CoV-2 in the first three months of the pandemic in an international cohort. METHODS: We surveyed 61 international sites with pediatric stroke expertise. Survey questions included: numbers of hospitalized pediatric (≤18 years) SARS-CoV-2 patients; numbers of incident neonatal and childhood ischemic strokes; frequency of SARS-CoV-2 testing for pediatric stroke patients; and numbers of stroke cases positive for SARS-CoV-2 March 1-May 31, 2020. RESULTS: Of 42 centers with SAR-CoV-2 hospitalization numbers, 8/971 (0.82%) with SARS-CoV-2 had ischemic strokes. Proportions of stroke cases positive for SARS-CoV-2 from March-May 2020 were: 1/108 neonatal AIS (0.9%), 0/33 neonatal cerebral sinovenous thrombosis (CSVT; 0%), 6/166 childhood AIS (3.6%), and 1/54 childhood CSVT (1.9%) cases. However, only 30.5% of neonates and 60% of children with strokes were tested for SARS-CoV-2. Therefore, these proportions represent 2.9%, 0%, 6.1%, and 3.0% of stroke cases tested for SARS-CoV-2. Seven of eight with SARS-CoV-2 had additional established stroke risk factors. INTERPRETATION: As in adults, pediatric stroke is an infrequent complication of SARS-CoV-2, and SARS-CoV-2 was detected in only 4.7% of pediatric ischemic stroke patients tested. However, <50% of strokes were tested. SARS-CoV-2 testing should be considered in pediatric stroke patients as the pandemic continues to determine SARS-CoV-2's role in pediatric stroke. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2 |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ana.25991 |
| Publisher version: | http://dx.doi.org/10.1002/ana.25991 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10118089 |
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