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Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease

Cuthbert, GA; Shaik, F; Harrison, MA; Ponnambalam, S; Homer-Vanniasinkam, S; (2020) Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease. Cells , 9 (11) , Article 2453. 10.3390/cells9112453. Green open access

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Abstract

The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and progression of atherosclerosis. Increasing interest in understanding SR structure and function has led to the idea that these proteins could provide new routes for cardiovascular disease diagnosis, management, and treatment. In this review, we consider the main classes of SRs that are implicated in arterial disease. We consider how our understanding of SR-mediated recognition of diverse ligands, including modified lipid particles, lipids, and carbohydrates, has enabled us to better target SR-linked functionality in disease. We also link clinical studies on vascular disease to our current understanding of SR biology and highlight potential areas that are relevant to cardiovascular disease management and therapy

Type: Article
Title: Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells9112453
Publisher version: https://doi.org/10.3390/cells9112453
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: scavenger receptors; atherosclerosis; cardiovascular disease; lipids
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10117966
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