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The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Bjedov, I; Rallis, C; (2020) The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Genes , 11 (9) , Article 1043. 10.3390/genes11091043. Green open access

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Abstract

Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.

Type: Article
Title: The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/genes11091043
Publisher version: http://dx.doi.org/10.3390/genes11091043
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Keywords: ageing, Drosophila, yeast, nutrient-response, autophagy, translation, transcription, metabolism, TORC1, TORC2, MESSENGER-RNA TRANSLATION, AMINO-ACID CONTROL, GENE-EXPRESSION, S6 KINASE, TRANSCRIPTION FACTORS, INSULIN-RESISTANCE, STRESS RESISTANCE, INDUCED OBESITY, POLYMERASE III, CELL-GROWTH
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10117834
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