UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A selective effect of dopamine on information-seeking

Vellani, V; de Vries, LP; Gaule, A; Sharot, T; (2020) A selective effect of dopamine on information-seeking. eLife , 9 , Article e59152. 10.7554/eLife.59152. Green open access

[thumbnail of elife-59152-v1.pdf]
Preview
Text
elife-59152-v1.pdf - Published version

Download (486kB) | Preview

Abstract

Humans are motivated to seek information from their environment. How the brain motivates this behavior is unknown. One speculation is that the brain employs neuromodulatory systems implicated in primary reward-seeking, in particular dopamine, to instruct information-seeking. However, there has been no causal test for the role of dopamine in information-seeking. Here, we show that administration of a drug that enhances dopamine function (dihydroxy-L-phenylalanine; L-DOPA) reduces the impact of valence on information-seeking. Specifically, while participants under Placebo sought more information about potential gains than losses, under L-DOPA this difference was not observed. The results provide new insight into the neurobiology of information-seeking and generates the prediction that abnormal dopaminergic function (such as in Parkinson's disease) will result in valence-dependent changes to information-seeking.

Type: Article
Title: A selective effect of dopamine on information-seeking
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.59152
Publisher version: http://dx.doi.org/10.7554/eLife.59152
Language: English
Additional information: Copyright © 2020, Vellani et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: decision-making, dopamine, human, information-seeking, neuroscience, reward
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10117668
Downloads since deposit
24Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item