UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models

Franklin, H; Clarke, BE; Patani, R; (2020) Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models. Progress in Neurobiology , Article 101973. 10.1016/j.pneurobio.2020.101973. (In press). Green open access

[thumbnail of Patani_1-s2.0-S0301008220302288-main (1).pdf]
Preview
Text
Patani_1-s2.0-S0301008220302288-main (1).pdf - Published version

Download (2MB) | Preview

Abstract

Both astrocytes and microglia fulfil homeostatic and immune functions in the healthy CNS. Dysfunction of these cell types have been implicated in the pathomechanisms of several neurodegenerative diseases. Understanding the cellular autonomy and early pathological changes in these cell types may inform drug screening and compound development. While animal models and post-mortem tissue have been invaluable in understanding disease pathomechanisms, the advent of human in vitro models provides a unique insight into disease biology as a manipulable model system obtained directly from patients. Here, we discuss the different human in vitro models of astrocytes and microglia and outline the phenotypes that have been recapitulated in these systems.

Type: Article
Title: Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pneurobio.2020.101973
Publisher version: https://doi.org/10.1016/j.pneurobio.2020.101973
Language: English
Additional information: Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Astrocyte; microglia; Neurodegenerative disease; human iPSC; in vitro
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10117576
Downloads since deposit
36Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item