UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Opportunistic bacterial, viral and fungal infections of the lung

José, RJ; Periselneris, JN; Brown, JS; (2020) Opportunistic bacterial, viral and fungal infections of the lung. Medicine , 48 (6) pp. 366-372. 10.1016/j.mpmed.2020.03.006. Green open access

[thumbnail of Opportunistic bacterial, viral and fungal infections of the lung.pdf]
Preview
Text
Opportunistic bacterial, viral and fungal infections of the lung.pdf - Published Version

Download (186kB) | Preview

Abstract

Opportunistic infections are a major cause of morbidity and mortality in severely immunocompromised patients, such as those given chemotherapy or biological therapies, and those with haematological malignancy, aplastic anaemia or HIV infection, or recipients of solid organ or stem cell transplants. The type and degree of immune defect dictates the profile of potential opportunistic pathogens; T-cell-mediated defects increase the risk of viral (cytomegalovirus, respiratory viruses) and Pneumocystis jirovecii infections, whereas neutrophil defects are associated with bacterial pneumonia and invasive aspergillosis. However, patients often have combinations of immune defects, and a wide range of other opportunistic infections can cause pneumonia. Importantly, conventional non-opportunistic pathogens are frequently encountered in immunocompromised hosts and should not be overlooked The radiological pattern of disease (best assessed by computed tomography) and speed of onset help identify the likely pathogen(s); this can then be supported by targeted investigation including early use of bronchoscopy in selected patients. Rapid and expert clinical assessment can identify the most likely pathogens, allowing timely appropriate therapy.

Type: Article
Title: Opportunistic bacterial, viral and fungal infections of the lung
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2020.03.006
Publisher version: https://doi.org/10.1016/j.mpmed.2020.03.006
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Aspergillus, Cryptococcus, MRCP, Nocardia, fungi, immunocompromised host, opportunistic infections, pneumonia, viruses
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10117565
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item