Blanchett, S; Boal-Carvalho, I; Layzell, S; Seddon, B; (2020) NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells. Trends in Immunology 10.1016/j.it.2020.10.013. (In press).

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Abstract

NF-κB signaling is required at multiple stages of T cell development and function. The NF-κB pathway integrates signals from many receptors and involves diverse adapters and kinases. Recent advances demonstrate that kinases controlling NF-κB activation, such as the IKK complex, serve dual independent functions because they also control cell death checkpoints. Survival functions previously attributed to NF-κB are in fact mediated by these upstream kinases by novel mechanisms. This new understanding has led to a refined view of how NF-κB and cell death signaling are interlinked and how they regulate cell fate. We discuss how NF-κB activation and control of cell death signaling by common upstream triggers cooperate to regulate different aspects of T cell development and function.

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