UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells

Blanchett, S; Boal-Carvalho, I; Layzell, S; Seddon, B; (2020) NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells. Trends in Immunology 10.1016/j.it.2020.10.013. (In press). Green open access

[thumbnail of PIIS147149062030257X.pdf]
Preview
Text
PIIS147149062030257X.pdf - Published Version

Download (1MB) | Preview

Abstract

NF-κB signaling is required at multiple stages of T cell development and function. The NF-κB pathway integrates signals from many receptors and involves diverse adapters and kinases. Recent advances demonstrate that kinases controlling NF-κB activation, such as the IKK complex, serve dual independent functions because they also control cell death checkpoints. Survival functions previously attributed to NF-κB are in fact mediated by these upstream kinases by novel mechanisms. This new understanding has led to a refined view of how NF-κB and cell death signaling are interlinked and how they regulate cell fate. We discuss how NF-κB activation and control of cell death signaling by common upstream triggers cooperate to regulate different aspects of T cell development and function.

Type: Article
Title: NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.it.2020.10.013
Publisher version: https://doi.org/10.1016/j.it.2020.10.013
Language: English
Additional information: This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: T cells, apoptosis, necroptosis, nuclear factor κB
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10117198
Downloads since deposit
80Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item