Kehinde, F;
Bharmal, AV;
Goodyer, IM;
Kelvin, R;
Dubicka, B;
Midgley, N;
Fonagy, P;
... Wilkinson, P; + view all
(2021)
Cross-sectional and longitudinal associations between psychotic and depressive symptoms in depressed adolescents.
European Child and Adolescent Psychiatry
(In press).
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Fonagy_ADAPT IMPACT Psychosis 5Dec20 final.pdf - Accepted version Access restricted to UCL open access staff until 3 June 2021. Download (294kB) |
Abstract
Adults with Major Depressive Disorder (MDD) with psychotic features (delusions and/or hallucinations) have more severe symptoms and a worse prognosis. Sub-clinical psychotic symptoms are more common in adolescents than adults. However, the effects of psychotic symptoms on outcome of depressive symptoms have not been well-studied in adolescents. Depressed adolescents aged 11-17 with and without psychotic symptoms were compared on depression severity scores at baseline and at 28 or 42 week follow-up in two large UK cohorts. Psychotic symptoms were weakly associated with more severe depression at baseline in both cohorts. At follow-up, baseline psychotic symptoms were only associated with depressive symptoms in one sample; in the other, the effect size was close to zero. This supports the DSM5 system of psychotic symptoms being a separate code to severity rather than the ICD10 system which only allows the diagnosis of psychotic depression with severe depression. There was no clear support for psychotic symptoms being a baseline marker of treatment response.
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