Bueno, CZ;
Apolinario, AC;
Duro-Castano, A;
Poma, A;
Pessoa, A;
Rangel-Yagui, CO;
Battaglia, G;
(2020)
L-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes.
ACS Macro Letters
, 9
(10)
pp. 1471-1477.
10.1021/acsmacrolett.0c00619.
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Abstract
This work reports, for the encapsulation of l-asparaginase, an anticancer enzyme into hybrid PMPC25–PDPA70/PEO16–PBO22 asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.
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