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L-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes

Bueno, CZ; Apolinario, AC; Duro-Castano, A; Poma, A; Pessoa, A; Rangel-Yagui, CO; Battaglia, G; (2020) L-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes. ACS Macro Letters , 9 (10) pp. 1471-1477. 10.1021/acsmacrolett.0c00619. Green open access

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Abstract

This work reports, for the encapsulation of l-asparaginase, an anticancer enzyme into hybrid PMPC25–PDPA70/PEO16–PBO22 asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.

Type: Article
Title: L-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsmacrolett.0c00619
Publisher version: https://doi.org/10.1021/acsmacrolett.0c00619
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10116933
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