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Theta power and theta‐gamma coupling support long‐term spatial memory retrieval

Vivekananda, U; Bush, D; Bisby, JA; Baxendale, S; Rodionov, R; Diehl, B; Chowdhury, FA; ... Burgess, N; + view all (2020) Theta power and theta‐gamma coupling support long‐term spatial memory retrieval. Hippocampus 10.1002/hipo.23284. Green open access

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Abstract

Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long‐term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perform a long‐term spatial memory task in desktop virtual reality and found that increased theta power in two discrete bands (“low” 2‐5 Hz and “high” 6‐11 Hz) during cued retrieval was associated with improved task performance. Similarly, increased coupling between “low” theta phase and gamma amplitude during the same period was associated with improved task performance. Finally, low and high gamma amplitude appeared to peak at different phases of the theta cycle; providing a novel connection between human hippocampal function and rodent data. These results help to elucidate the role of theta oscillations and theta‐gamma phase‐amplitude coupling in human long‐term memory.

Type: Article
Title: Theta power and theta‐gamma coupling support long‐term spatial memory retrieval
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.23284
Publisher version: https://doi.org/10.1002/hipo.23284
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: gamma, hippocampus, phase amplitude coupling, spatial memory, theta
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10116836
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