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Impact of Bioresorbable Scaffold Design Characteristics on Local Hemodynamic Forces - An Ex Vivo Assessment With Computational Fluid Dynamics Simulations

Tarrahi, I; Colombo, M; Hartman, EMJ; Natalia, M; Forero, T; Torii, R; Chiastra, C; ... Gijsen, FJH; + view all (2020) Impact of Bioresorbable Scaffold Design Characteristics on Local Hemodynamic Forces - An Ex Vivo Assessment With Computational Fluid Dynamics Simulations. EuroIntervention , 16 e930-e937. 10.4244/EIJ-D-19-00657.

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Abstract

AIMS:Bioresorbable scaffold (BRS) regions exposed to flow recirculation, low time-averaged wall shear stress (TAWSS) and high oscillatory shear index (OSI) develop increased neointima tissue. We investigated haemodynamic features in four different BRSs. METHODS AND RESULTS: Fantom (strut height [SH] = 125 µm), Fantom Encore (SH = 98 µm), Absorb (SH = 157 µm) and Magmaris (SH = 150 µm) BRSs were deployed in phantom tubes and imaged with microCT. Both 2D and 3D geometrical scaffold models were reconstructed. Computational fluid dynamics (CFD) simulation was performed to compute TAWSS and OSI. Thicker struts had larger recirculation zones and lower TAWSS in 2D. Absorb had the largest recirculation zone and the lowest TAWSS (240 µm and −0.18 Pa), followed by Magmaris (170 µm and −0.15 Pa), Fantom (140 µm and −0.14 Pa) and Fantom Encore (100 µm and −0.13 Pa). Besides strut size, stent design played a dominant role in 3D. The highest percentage area adverse TAWSS (<0.5 Pa) and OSI (>0.2) were found for Fantom (56% and 30%) and Absorb (53% and 33%), followed by Fantom Encore (30% and 25%) and Magmaris (25% and 20%). Magmaris had the smallest areas due to a small footprint and rounded struts. CONCLUSIONS: Due to stent design, both Fantom Encore and Magmaris showed smaller TAWSS and OSI than Fantom and Absorb. This study quantifies which scaffold features are most important to reduce long-term restenosis.

Type: Article
Title: Impact of Bioresorbable Scaffold Design Characteristics on Local Hemodynamic Forces - An Ex Vivo Assessment With Computational Fluid Dynamics Simulations
DOI: 10.4244/EIJ-D-19-00657
Publisher version: http://doi.org/10.4244/EIJ-D-19-00657
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: bioresorbable scaffolds, in-stent restenosis, preclinical research
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10116748
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