Stotesbury, H;
Murdoch, R;
Hales, P;
Kawadler, J;
Kolbel, M;
Carmichael, D;
Clark, C;
... Shmueli, K; + view all
(2020)
Venous oxygenation in sickle cell patients and controls using quantitative susceptibility mapping versus T2- relaxation-under-spin-tagging.
In:
Proceedings of the 2020 ISMRM & SMRT VIRTUAL CONFERENCE & EXHIBITION.
(pp. pp. 1-3).
International Society for Magnetic Resonance in Medicine (ISMRM)
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Abstract
In 15 homozygous sickle-cell disease patients (SCD; hemoglobin-SS) and 12 healthy controls (HC; 10 Hb-AA, 2 Hb-AS), we compared a quantitative susceptibility mapping (QSM)-based estimate of venous oxygen saturation (Yv) with T2-relaxation-under-spin-tagging (TRUST)-based estimates using bovine-hemoglobin (TRUST-HbBV), hemoglobin-S (TRUST-HbS), or hemoglobin-A (TRUST-HbA) calibrations. Agreement between methods varied, with QSM-Yv estimates in HC and SCD respectively on average 5-6% higher versus TRUST-HbBV, 5% higher and 9% lower versus TRUST-HbS, and 9% higher and 2% lower versus TRUST-HbA. Across all comparisons, the limits of agreement were wide (18-26%) underscoring the need for further studies comparing non-invasive methods with gold-standard jugular vein catheterization.
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