Murdoch, R;
Kawadler, J;
Kirkham, F;
Shmueli, K;
(2018)
Investigating the effect of prior stroke on regional brain iron concentrations in children with sickle cell anaemia using MRI susceptibility mapping.
In:
Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018. SMRT 27th Annual Meeting.
(pp. pp. 1-3).
: International Society for Magnetic Resonance in Medicine (ISMRM).
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Abstract
Regional iron concentrations in the brains of children with Sickle Cell Anaemia Regional iron concentrations in the brains of children with Sickle Cell Anaemia (SCA) were examined using susceptibility mapping (SM), in the (SCA) were examined using susceptibility mapping (SM), in the fifirst study to apply rst study to apply SM to an African cohort in Tanzania. Mean susceptibility values in three deep- SM to an African cohort in Tanzania. Mean susceptibility values in three deepbrain regions were compared to age, blood ferritin levels and history of clinical brain regions were compared to age, blood ferritin levels and history of clinical stroke. Mean susceptibility values increased linearly with age, but there was no stroke. Mean susceptibility values increased linearly with age, but there was no signi signifificant correlation between susceptibility values and blood ferritin levels. cant correlation between susceptibility values and blood ferritin levels. SCA patients who had su SCA patients who had suffffered stroke prior to MRI had signi ered stroke prior to MRI had signifificantly lower cantly lower susceptibility values than stroke-free patients. This may suggest a role for iron susceptibility values than stroke-free patients. This may suggest a role for iron dedefificiency in stroke in SCA. ciency in stroke in SCA.
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