Waller, Z;
King, JJ;
Irving, KL;
Evans, CW;
Becker, R;
Christ, D;
Hurley, LH;
... Smith, NM; + view all
(2020)
DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells.
Journal of the American Chemical Society
, 142
(49)
pp. 20600-20604.
10.1021/jacs.0c11708.
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Abstract
Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.
| Type: | Article |
|---|---|
| Title: | DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/jacs.0c11708 |
| Publisher version: | https://doi.org/10.1021/jacs.0c11708 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Structural dynamics, Ligands, Genetics, Chemical structure, Stabilization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10116276 |
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