Chambers, ES;
Vukmanovic-Stejic, M;
Turner, CT;
Shih, BB;
Trahair, H;
Pollara, G;
Tsaliki, E;
... Akbar, AN; + view all
(2020)
Vitamin D₃ replacement enhances antigen-specific immunity in older adults.
Immunotherapy Advances
10.1093/immadv/ltaa008.
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Abstract
Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D increases immunoregulatory mechanisms and has the potential to inhibit inflammageing. Since vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. Therefore we investigated the use of vitamin D3 replacement to enhance cutaneous antigen-specific immunity in older adults (≥65 years). We showed that that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. Therefore, vitamin D3 replacement was investigated to determine if it could improve VZV-specific cutaneous immune responses in older adults. Vitamin D insufficient older adults (n=18) were administered 6400IU of vitamin D3/day orally for 14 weeks. Antigen-specific immunity to VZV was assessed using transcriptional analysis of skin biopsies collected from challenged injection sites pre- and post-vitamin D3 replacement. We showed that vitamin D3 supplementation significantly increased the response to cutaneous VZV antigen challenge in older adults. This enhancement was associated with a reduction in inflammatory monocyte infiltration with a concomitant enhancement of T cell recruitment to the site of antigen challenge in the skin. In conclusion vitamin D3 replacement can boost antigen-specific immunity in older adults with sub-optimal vitamin D status.
| Type: | Article |
|---|---|
| Title: | Vitamin D₃ replacement enhances antigen-specific immunity in older adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/immadv/ltaa008 |
| Publisher version: | https://doi.org/10.1093/immadv/ltaa008 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10116188 |
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