Gunasekeran, DV;
Agrawal, R;
Testi, I;
Agarwal, A;
Mahajan, S;
Nguyen, QD;
Pavesio, C;
(2020)
Lessons in Digital Epidemiology from COTS-1: Coordinating Multicentre Research across 10 Countries Using Operational and Technology Innovation to Overcome Funding Deficiencies.
Ocular Immunology and Inflammation
10.1080/09273948.2020.1744669.
(In press).
Preview |
Text
Pavesio_Lessons in digital epidemiology from COTS-1.pdf - Accepted Version Download (518kB) | Preview |
Abstract
Purpose: There is controversy regarding the diagnosis and management of ocular tuberculosis (TB) due to lack of robust evidence. The Collaborative Ocular Tuberculosis Study (COTS) was conducted in stages to enable swift, accurate data collection across 25 participating centers. Method: Data collection was facilitated by a cloud-based data aggregation platform with programmed logic based on anecdotal evidence from uveitis experts corroborated with literature review. Results: The platform enabled standardization of interpretation and collection of data from patient medical records. The pre-programmed logic also ensured the platform only prompted the entry of relevant data based on initial data entered for each unit of analysis. This enabled collection of the vast amounts of data without compromising either of the breadth nor the depth of data collection. Conclusion: The final output from this effort was an in-depth retrospective analysis to facilitate the design of future prospective investigations on ocular TB and develop best practice guidelines.
Type: | Article |
---|---|
Title: | Lessons in Digital Epidemiology from COTS-1: Coordinating Multicentre Research across 10 Countries Using Operational and Technology Innovation to Overcome Funding Deficiencies |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1080/09273948.2020.1744669 |
Publisher version: | https://doi.org/10.1080/09273948.2020.1744669 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Clinical research, Collaborative Ocular Tuberculosis Study (COTS), methodology, multi-center investigation, ocular tuberculosis, tuberculosis |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10116088 |
Archive Staff Only
View Item |