UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Insights into the molecular pathogenesis of ocular tuberculosis

Agrawal, R; Testi, I; Rousselot, A; Chen, EJ; Lakshminarayanan, R; Singhal, A; Bundele, M; ... Pavesio, C; + view all (2021) Insights into the molecular pathogenesis of ocular tuberculosis. Tuberculosis , 126 , Article 102018. 10.1016/j.tube.2020.102018. (In press).

[img] Text
Pavesio_Insights into the pat of OTB.pdf - Accepted version
Access restricted to UCL open access staff until 13 November 2021.

Download (559kB)

Abstract

Unclear pathogenic mechanisms underlying the ocular tuberculosis (OTB) has resulted in perplexity related to the diagnosis and management of the disease. Developments in experimental research and innovations in molecular diagnostics have recently provided a new understanding of disease pathogenesis and natural history. The current review focuses on the new insights into OTB pathogenesis, derived from in vivo and in vitro studies on Mycobacterium tuberculosis dissemination and localization into the eye, in combination with histopathological studies on chorioretinal tissue and vascular network. Advances in the knowledge of OTB have influenced disease management in the clinical setting and lead to reconsideration of the role of existing treatments and suggesting potential new therapeutic approaches.

Type: Article
Title: Insights into the molecular pathogenesis of ocular tuberculosis
DOI: 10.1016/j.tube.2020.102018
Publisher version: https://doi.org/10.1016/j.tube.2020.102018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ocular tuberculosis, tubercular uveitis, paediatric population, children, Collaborative Ocular Tuberculosis Study (COTS)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10116086
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item