Agrawal, R;
Testi, I;
Rousselot, A;
Chen, EJ;
Lakshminarayanan, R;
Singhal, A;
Bundele, M;
... Pavesio, C; + view all
(2021)
Insights into the molecular pathogenesis of ocular tuberculosis.
Tuberculosis
, 126
, Article 102018. 10.1016/j.tube.2020.102018.
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Abstract
Unclear pathogenic mechanisms underlying the ocular tuberculosis (OTB) has resulted in perplexity related to the diagnosis and management of the disease. Developments in experimental research and innovations in molecular diagnostics have recently provided a new understanding of disease pathogenesis and natural history. The current review focuses on the new insights into OTB pathogenesis, derived from in vivo and in vitro studies on Mycobacterium tuberculosis dissemination and localization into the eye, in combination with histopathological studies on chorioretinal tissue and vascular network. Advances in the knowledge of OTB have influenced disease management in the clinical setting and lead to reconsideration of the role of existing treatments and suggesting potential new therapeutic approaches.
| Type: | Article |
|---|---|
| Title: | Insights into the molecular pathogenesis of ocular tuberculosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tube.2020.102018 |
| Publisher version: | https://doi.org/10.1016/j.tube.2020.102018 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Ocular tuberculosis, tubercular uveitis, paediatric population, children, Collaborative Ocular Tuberculosis Study (COTS) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10116086 |
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