Chan, JM;
Gori, A;
Nobbs, AH;
Heyderman, RS;
(2020)
Streptococcal Serine-Rich Repeat Proteins in Colonization and Disease.
Frontiers in Microbiology
, 11
, Article 593356. 10.3389/fmicb.2020.593356.
Preview |
Text
fmicb-11-593356.pdf - Published Version Download (2MB) | Preview |
Abstract
Glycosylation of proteins, previously thought to be absent in prokaryotes, is increasingly recognized as important for both bacterial colonization and pathogenesis. For mucosal pathobionts, glycoproteins that function as cell wall-associated adhesins facilitate interactions with mucosal surfaces, permitting persistent adherence, invasion of deeper tissues and transition to disease. This is exemplified by Streptococcus pneumoniae and Streptococcus agalactiae, which can switch from being relatively harmless members of the mucosal tract microbiota to bona fide pathogens that cause life-threatening diseases. As part of their armamentarium of virulence factors, streptococci encode a family of large, glycosylated serine-rich repeat proteins (SRRPs) that facilitate binding to various tissue types and extracellular matrix proteins. This minireview focuses on the roles of S. pneumoniae and S. agalactiae SRRPs in persistent colonization and the transition to disease. The potential of utilizing SRRPs as vaccine targets will also be discussed.
| Type: | Article |
|---|---|
| Title: | Streptococcal Serine-Rich Repeat Proteins in Colonization and Disease |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2020.593356 |
| Publisher version: | https://doi.org/10.3389/fmicb.2020.593356 |
| Language: | English |
| Additional information: | © 2020 Chan, Gori, Nobbs and Heyderman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Streptococcus agalactiae, Streptococcus pneumoniae, bacterial glycoproteins, colonization, pathogenesis, serine-rich repeat proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10115837 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
