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Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Martins-Marques, T; Hausenloy, DJ; Sluijter, JPG; Leybaert, L; Girao, H; (2020) Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia. Trends in Molecular Medicine 10.1016/j.molmed.2020.10.002. (In press).

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Abstract

The maintenance of tissue, organ, and organism homeostasis relies on an intricate network of players and mechanisms that assist in the different forms of cell–cell communication. Myocardial infarction, following heart ischemia and reperfusion, is associated with profound changes in key processes of intercellular communication, involving gap junctions, extracellular vesicles, and tunneling nanotubes, some of which have been implicated in communication defects associated with cardiac injury, namely arrhythmogenesis and progression into heart failure. Therefore, intercellular communication players have emerged as attractive powerful therapeutic targets aimed at preserving a fine-tuned crosstalk between the different cardiac cells in order to prevent or repair some of harmful consequences of heart ischemia and reperfusion, re-establishing myocardial function.

Type: Article
Title: Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia
Location: England
DOI: 10.1016/j.molmed.2020.10.002
Publisher version: https://doi.org/10.1016/j.molmed.2020.10.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: acute myocardial infarction, cardioprotection, extracellular vesicles, gap junctions, intercellular communication, remote ischemic conditioning
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10115414
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